发明名称 |
A METHOD OF MODULATING B CELL FUNCTIONING |
摘要 |
<p>The present invention relates generally to a method of modulating cellular functioning. More particularly, the present invention relates to a method of modulating B cell functioning, for example B cell proliferation, utilising an IDO- mediated tryptophan metabolite as herein defined (particular examples of such IDO-mediated tryptophan metabolites include 3-hydroxykynurenic acid, 3-hydroxyanthranilic acid, picolinic acid, quinolinic acid and tranilast). The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate B cell functioning such as antibody production, autoimmune conditions and B cell proliferation and neoplasias. In a related aspect, the present invention is directed to a method of therapeutically and/or prophylactically treating rheumatoid arthritis via the administration of the above-mentioned compounds.</p> |
申请公布号 |
WO2006053390(A1) |
申请公布日期 |
2006.05.26 |
申请号 |
WO2005AU01754 |
申请日期 |
2005.11.17 |
申请人 |
ANGIOGEN PHARMACEUTICALS PTY. LTD.;SELLEY, MICHAEL LIONEL;INGLIS, JULIA JANE;WILLIAMS, RICHARD OWEN |
发明人 |
SELLEY, MICHAEL LIONEL;INGLIS, JULIA JANE;WILLIAMS, RICHARD OWEN |
分类号 |
A61K31/44;A61K31/167;A61K31/4402;A61K31/47;A61P3/10;A61P7/06;A61P17/06;A61P25/02;A61P29/00;A61P35/00;A61P35/02;A61P37/06 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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