Antigen presenting cell targeting conjugate, an antigen presenting cell contacted with such conjugate, their use for vaccination or as medicament, and methods for their production or generation

摘要

A conjugate for targeting antigen presenting cells comprises at least one antigenic moiety conjugated to a targeting moiety that is capable of binding to a cell surface structure of an antigen presenting cell and that upon binding to an antigen presenting cell induces a CTL response and a T-helper response. The targeting moiety is capable of binding CD33+ CD14- dendritic cell and CD33dim CD16- dendritic cells and is essentially incapable of binding CD3+ T cells and CD56+ NK cells. Preferably the targeting moiety is an IgG4 immunoglobin. Pharmaceutical compositions comprising the conjugate or comprising antigen presenting cells contacted with the conjugate are useful for vaccinations, as an anti-parasitic, anti-fungal, anti-bacterial, anti-viral or anti-tumor agent, and for the prevention and treatment of diseases such as Alzheimer's , atherosclerosis, cancer diabetes, AIDS, and hepatitis.