发明名称 BETA-AMINO ACID NITRILE DERIVATIVES
摘要 The present invention relates to compound of formula (I) wherein R1, R2, R3, R4, R5 and n are as defined in the description and claims and pharmaceutically acceptable stalts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment of diseases which are associated with cysteine proteases such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, instable angina pectoris, stroke, plaque rupture, transient ischemic attacks, amaurosis fugax, peripheral arterial occlusive disease, restenosis after angioplasty and stent placement, abdominal aortic aneurysm formation, inflammation, autoimmune disease, malaria, ocular fundus tissue cytopathy and respiratory disease.
申请公布号 YU90802(A) 申请公布日期 2006.05.25
申请号 YU2002P000908 申请日期 2001.06.08
申请人 F. HOFFMANN-LA ROCHE AG. 发明人 GABRIEL, TOBIAS;PECH, MICHAEL;RODRIGUEZ, SARMIENTO ROSA M.
分类号 A61K31/277;A61K31/343;A61K31/357;A61K31/36;A61K31/381;A61K31/42;A61K31/4245;A61K31/498;A61P7/00;A61P9/00;A61P9/08;A61P9/10;A61P13/12;A61P19/02;A61P19/10;A61P33/06;A61P35/00;A61P37/02;C07C253/30;C07C255/29;C07C255/31;C07C255/44;C07C269/06;C07C271/24;C07C271/36;C07C271/56;C07C303/40;C07C311/07;C07C311/13;C07C311/20;C07C311/46;C07C319/20;C07C323/52;C07C323/60;C07D241/44;C07D261/18;C07D271/12;C07D307/85;C07D317/60;C07D333/16;C07D333/32;C07D333/40 主分类号 A61K31/277
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