发明名称 |
PYRAZOLE DERIVATIVES FOR TREATING HIV |
摘要 |
<p>This invention relates to pyrazole derivatives of the formula, or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implacated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Aquired Immune Deficiency Syndrome (AIDS).</p> |
申请公布号 |
YU77503(A) |
申请公布日期 |
2006.05.25 |
申请号 |
YU2003P000775 |
申请日期 |
2002.04.04 |
申请人 |
PFIZER INC. |
发明人 |
JONES, LYN HOWARD;MOWBRAY, CHARLES ERIC;PRICE, DAVID ANTHONY;SELBY, MATTHEW DUNCAN;STUPPLE, PAUL ANTHONY |
分类号 |
A61K;A61K31/415;A61K31/4155;A61K31/4178;A61K31/4196;A61K31/424;A61K31/4245;A61K31/4439;A61K31/454;A61K31/455;A61K31/496;A61K31/4985;A61K31/501;A61K31/506;A61K31/513;A61K31/5377;A61K31/675;A61K31/683;A61P;A61P31/18;A61P37/02;A61P43/00;C07D;C07D231/18;C07D231/20;C07D231/28;C07D231/38;C07D401/06;C07D401/12;C07D403/04;C07D403/06;C07D403/12;C07D405/12;C07D405/14;C07D409/12;C07D413/06;C07D413/12;C07D471/04;C07D487/04;C07D498/04;C07D521/00;C07F9/6503 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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