发明名称 |
GENE ASSOCIATED WITH LEISHMANIA PARASITE VIRULENCE |
摘要 |
The invention relates to the field of combating leishmaniases. Said invention results from the isolation, from wild isolates of Leishmania major, of a protein- coding gene known as LmPDI which has two regions that are identical to the sequence (Cys-Gly-His- Cys) of the potential active site of the protein disulphide isomerases (PDI). The LmPDI protein is predominantly expressed in the most virulent isolates of the parasite. Said protein forms a novel therapeutic target for developing anti-leishmaniasis medicaments and a novel element that can be used in the composition of immunogenic, and possibly vaccinating, preparations which are intended to protect a human or animal host against Leishmania. |
申请公布号 |
YU99603(A) |
申请公布日期 |
2006.05.25 |
申请号 |
YU2003P000996 |
申请日期 |
2002.06.17 |
申请人 |
INSTITUT PASTEUR DE TUNIS;INSTITUT PASTEUR |
发明人 |
BEN, ACHOUR YOSSER;CHENIK, MEHDI;LOUZIR, HECHMI;DELLAGI, KOUSSAY |
分类号 |
G01N33/50;A61K39/00;A61K39/395;A61K45/00;A61P33/02;A61P43/00;C07K16/20;C07K19/00;C12N1/21;C12N9/90;C12N15/09;C12N15/30;C12N15/61;C12Q1/04;C12Q1/18;C12Q1/34;C12Q1/68;C12R1/90;G01N33/15;G01N33/569 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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