Immune globulin formulations for the treatment and prevention of an orthopoxvirus infection

摘要

The invention provides an immune globulin having a high titre of antibody to Orthopoxvirus, pharmaceutical compositions comprising the immune globulin and methods for making same. In one embodiment the immune globulin is intravenously injectable. The invention also provides a colorimetric assay to detect neutralizing antibodies to vaccinia virus. The invention has a number of uses including detection of neutralizing antibodies to vaccinia virus and the immunization of persons against the Orthopoxvirus and in the treatment of related conditions.