| 摘要 |
1,181,146. Bis - thiosemicarbazones. FARBWERKE HOECHST A.G. 12 May, 1967 [14 May, 1966], No. 22092/67. Heading C2C. Novel compounds (I) in which R represents a dimethylamino, diethylamino, pyrrolidino or piperidino group are prepared: (a) by reacting a mono-thiosemicarbazone, Me.C( : X).CMe : NOH wherein X is the radical : N.NH.CSNH.CH 2 CH 2 CH 2 R or : N.NH.CSNHCH 2 CHMe 2 , with a thiosemicarbazide, H 2 N.NHGSNH.CH 2 CHMe 2 or H 2 N.NHCSNH(CH 2 ) 3 R; or (b) by reacting a mono-thiosemicarbazone, Me.C ( : X).CMe : N.NH 2 , with an isothiocyanate, S = C = N.CH 2 .CHMe 2 or S = C = N.(CH 2 ) 3 R. Interaction of diacetyl-dihydrazone and the appropriate isothiocyanate affords the following starting materials: diacetyl-mono-(3-dimethyl- or 3 - diethyl - aminopropyl - thiosemicarbazone) - mono - hydrazone, diacetyl - mono - isobutyl - thiosemicarbazone - mono - hydrazone and diacetyl - mono - (3 - pyrrolidino - or 3 - piperidino - propyl - thiosemicarbazone)- mono - hydrazone. Pharmaceutical compositions active against coccidiosis contain as the active ingredient the above novel compounds. Administration is by means of a foodstuff or drinking water. |
