发明名称 |
RECONSTITUTABLE PARENTERAL COMPSITION CONTAINING A COX-2 INHIBITOR |
摘要 |
A pharmaceutical composition comprises, in powder form, (a) at least one water-soluble therapeutic agent selected from selective COX-2 inhibitory drugs and prodrugs and salts thereof, for example parecoxib sodium, in a therapeutically effective total amount constituting about 30% to about 90% by weight, (b) a parenterally acceptable buffering agent in an amount of about 5% to about 60% by weight, and optionally (c) other parenterally acceptable excipient ingredients in a total amount not greater than about 10% by weight, of the composition. The composition is reconstitutable in a parenterally acceptable solvent liquid to form an injectable solution. A lyophilization process is provided for preparation of such a composition. |
申请公布号 |
YU85803(A) |
申请公布日期 |
2006.05.25 |
申请号 |
YU2003P000858 |
申请日期 |
2002.04.02 |
申请人 |
PHARMACIA CORPORATION |
发明人 |
KARARLI, TUGRUL T.;NEMA, SANDEEP;KARIM, AZIZ |
分类号 |
C07D237/16;A61K9/00;A61K9/08;A61K9/19;A61K31/00;A61K31/122;A61K31/352;A61K31/365;A61K31/415;A61K31/42;A61K31/444;A61K31/50;A61K45/08;A61K47/02;A61K47/04;A61K47/12;A61K47/18;A61K47/36;A61P29/00;C07D213/61;C07D231/12;C07D261/08;C07D307/58;C07D311/58 |
主分类号 |
C07D237/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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