1-PHENYLSULFONYL-3-PHENYL-3-PYRROLIDINYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES AS ARGININE-VASOPRESSIN V1b RECEPTOR ANTAGONISTS

摘要

A 1,3-dihydro-2H-indol-2-one derivative expressed by Formula 1 (wherein R 1 is a halogen atom, a C 1 to C 4 alkyl group, etc., and R 2 is a hydrogen atom, a halogen atom, etc., or R 2 is in the 6-position of the indol-2-one and R 1 and R 2 join together to form a C 3 to C 6 alkylene group, R 3 is a halogen atom, a hydroxyl group, etc., and R 4 is a hydrogen atom, a halogen atom, a C 1 to C 4 alkyl group, etc., or R 4 is in the 3-position of the phenyl and R 3 and R 4 join together to form a methylenedioxy group, R 5 is a hydrogen atom or a fluorine atom, R 6 is an ethylamino group, a dimethylamino group, etc., R 7 is a C 1 to C 4 alkoxy group, and R 8 is a C 1 to C 4 alkoxy group), or a pharmaceutically acceptable salt of this derivative. This is a novel compound that has antagonistic activity against an aruginine-vasopressin V1b receptor.