发明名称 Pyrrolbenzodiazepines
摘要 Compounds of formula (Ia) and (Ib) wherein A is CH<SUB>2</SUB>, or a single bond; R<SUB>2 </SUB>is selected from: R, OH, OR, CO<SUB>2</SUB>H, CO<SUB>2</SUB>R, COH, COR, SO<SUB>2</SUB>R, CN; R<SUB>6</SUB>, R<SUB>7 </SUB>and R<SUB>9 </SUB>are independently selected from H, R, OH, OR, halo, amino, NHR, nitro, Me<SUB>3</SUB>Sn; and R<SUB>8 </SUB>is selected from H, R, OH, OR, halo, amino, NHR, nitro, Me<SUB>3</SUB>Sn, where R is as defined above, or the compound is a dimer with each monomer being the same or different and being of formula (Ia) or (Ib), where the R<SUB>8 </SUB>groups of the monomers form together a bridge having the formula -X-R'-X- linking the monomers, where R' is an alkylene chain containing from 3 to 12 carbon atoms, which chain may be interrupted by one or more hetero-atoms and/or aromatic rings and may contain one or more carbon-carbon double or triple bonds, and each X is independently selected from O, S, or N; except that in a compound of formula (Ia) when A is a single bond, then R<SUB>2 </SUB>is not CH-CH(CONH<SUB>2</SUB>) or CH-CH(CONMe<SUB>2</SUB>). Other related compounds are also disclosed
申请公布号 US7049311(B1) 申请公布日期 2006.05.23
申请号 US20010763767 申请日期 2001.02.26
申请人 发明人
分类号 A61K31/55;A61K31/5517;A61P31/00;A61P31/04;A61P31/12;A61P33/00;A61P35/00;C07D223/10;C07D487/00;C07D487/04;C07D519/00 主分类号 A61K31/55
代理机构 代理人
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