发明名称 |
POLYMERIC DRUG FORMULATIONS |
摘要 |
Polymeric drug formulations containing a non-releasing single-phase dispersi on of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix. Polymeric drug formulations are also disclosed containing a single-phase dispersion of a water-soluble drug and a water-insoluble tissue-compatible polymer matrix, and a second, phase- disrupting polymer that is non-miscible with the tissue-compatible polymer and is present in an amount sufficient to form phase-separated microdomains of the second polymer in the tissue-compatible polymer matrix, so that the release rate of the water-soluble drug from the tissue-compatible polymer matrix is related to the amount of the second polymer. Methods of preparing the polymeric drug formulations are also described, as well as methods for site-specific drug delivery utilizing the polymeric drug formulations.
|
申请公布号 |
CA2227792(C) |
申请公布日期 |
2006.05.23 |
申请号 |
CA19962227792 |
申请日期 |
1996.07.16 |
申请人 |
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY;EMORY UNIVERSITY |
发明人 |
KOHN, JOACHIM B.;HANSON, STEPHEN R.;BROCCHINI, STEPHEN |
分类号 |
A61K47/30;A61K9/10;A61K9/14;A61K9/20;A61K9/70;A61K31/70;A61K38/04;A61K38/17;A61K39/395;A61L27/00;A61L27/34;A61L27/54;A61L33/00;A61L33/12 |
主分类号 |
A61K47/30 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|