发明名称 |
1-[(4-methyl thio)phenyl]-2-(phenyl acetoxy)-1-ethanone and a process for preparing the same |
摘要 |
This invention relates to 1-[(4-methyl thio)phenyl]-2-(phenyl acetoxy)-1-ethanone. This compound is convertible into 4-(4-methyl thio phenyl)-3-phenyl-2 (5H)-furanone by an economically viable process. This substituted furanone is an intermediate or starting compound for synthesising COX II inhibitor Rofecoxib. This invention also includes a process for preparing the ethanone derivative by halogenating methyl thio aceto phenone and coupling the resulting 2 halosubstituted ethanone with sodium salt of phenyl acetic acid to obtain 1-[(4-methyl thio) phenyl]-2-(phenyl acetoxy)-1-ethanone.
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申请公布号 |
US7049459(B2) |
申请公布日期 |
2006.05.23 |
申请号 |
US20040491579 |
申请日期 |
2004.04.02 |
申请人 |
SHASUN CHEMICALS AND DRUGS LIMITED |
发明人 |
VITTAL TANGIRAJA VENKATA SUBRAMANYA KRISHNA;KRISHNA MUDDULURU HARI |
分类号 |
C07C321/00;C07C49/76;C07C69/76;C07C323/22;C07D305/12;C07D307/38;C07D407/00 |
主分类号 |
C07C321/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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