发明名称 |
Detection of DNA damaging agents |
摘要 |
Recombinant DNA molecules comprising a regulatory element that activates gene expression in response to DNA damage operatively linked to a DNA sequence that encodes a light emitting reporter protein, recombinant vectors containing such DNA molecules and cells containing the DNA molecules or recombinant vectors. A method of detecting for the presence of an agent that causes or potentiates DNA damage is also disclosed which involves subjecting the above-described cells to a putative DNA damaging agent and monitoring the expression of the light emitting reporter protein from the cell. |
申请公布号 |
US7049071(B2) |
申请公布日期 |
2006.05.23 |
申请号 |
US20020244292 |
申请日期 |
2002.09.16 |
申请人 |
UNIVERSITY OF MANCHESTER INSTITUTE OF SCIENCE ANDTECHNOLOGY |
发明人 |
WALMSLEY RICHARD MAURICE;HEYER WOLF-DIETRICH |
分类号 |
C12N15/09;C12Q1/68;C07K14/395;C07K14/435;C12N1/19;C12N15/12;C12N15/81;C12Q1/02;G01N33/50 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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