发明名称 Process and Intermediates to Prepare Latanoprost
摘要 The present invention is a novel intermediate, compound of the formula (VI)and salts thereof. In addition, the invention includes a process for the preparation of a 15(S)-prostaglandin intermediates compounds (IV) and (XVIII) which comprises (1) contacting a the corresponding enone with (-)-chlorodiisopinocampheylborane while maintaining the reaction mixture temperature in the range of from about -50° to about 0° and (2) contacting the reaction mixture of step (1) with a boron complexing agent.
申请公布号 KR100581647(B1) 申请公布日期 2006.05.22
申请号 KR20047000521 申请日期 2002.06.24
申请人 发明人
分类号 C07C59/54;C07D307/83;A61K31/5575;A61P27/02;C07C59/11;C07C59/72;C07C405/00;C07D307/935 主分类号 C07C59/54
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