DETERMINATION OF THE 3D-STRUCTURE OF AN EXTRACELLULAR DOMAIN OF A B1 G-PROTEIN COUPLED RECEPTOR BY NMR ANALYSIS
摘要
The present invention relates to a method for identifying modulators of B1 G-protein coupled receptors. The present invention also relates to a method for identifying an antagonist or agonist of the corticotropin-releasing factor receptor 2 (CRFR2). The present invention also relates to a method for improving antagonists or agonists of CRFR2. The present invention also relates to the three-dimensional structure of CRFR2 as representative of the B1 GPCR subfamily and its use as a basis for rational drug design of antagonist or agonists of B1 GPCRs.
申请公布号
WO2006031322(A3)
申请公布日期
2006.05.18
申请号
WO2005US28231
申请日期
2005.08.09
申请人
RESEARCH DEVELOPMENT FOUNDATION;ROYAPPA, GRACE, CHRISTY, RANI;PERRIN, MARILYN, H.;RIVIER, JEAN, E.;VALE, WYLIE, W.;RIEK, ROLAND