| 摘要 |
Novel processes for the preparation of amorphous atorvastatin hemi-calcium salt are provided, which involve dissolving atorvastatin hemi-calcium salt in certain organic solvents, and removing the solvent such as by spray drying, rapid vacuum evaporation, and/or thin film evaporation. Preferred embodiments of these processes for preparing amorphous atorvastatin hemi-calcium salt are reproducible, applicable on a large scale, and do not involve the use of hydrocarbons.
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