The invention relates to isolated polypeptides with hydantoin recemase activity, that do not suffer from substrate inhibition. Such polypeptides arc for instance isolated polypeptides with at least 87% identity with SEQ ID: NO. 2 or SEQ ED: NO. 4. The invention also relates to nucleic acid sequences encoding these polypeptides. The invention also relates to processes for the racemisation of enantiomerically enriched hydantoin compounds and to processes for the preparation of enantiomarically enriched I)-or I-α amino acids.
申请公布号
DE60304332(D1)
申请公布日期
2006.05.18
申请号
DE2003604332
申请日期
2003.05.23
申请人
DSM IP ASSETS B.V., HEERLEN
发明人
BOESTEN, HUBERTUS;KIERKELS, GERARDUS;ASSEMA, BERNARD;RUIZ PEREZ, MIGUEL;GONZALEZ PACANOWSKA, DOLORES;GONZALEZ LOPEZ, JESUS;DE LA ESCALERA HUESO, SANTIAGO