The present invention discloses a double transgenic fly that expresses both Tau protein and the human Aß42 peptide of human amyloid-ß precursor protein (APP). The double transgenic flies of the present invention display a synergistic altered phenotype as compared to the altered phenotype displayed by transgenic flies expressing either Tau or human Aß42 alone, and thus provide for an improved model for neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying for therapeutic compounds to treat neurodegenerative disorders using the double transgenic flies.
申请公布号
WO2005117577(A3)
申请公布日期
2006.05.18
申请号
WO2005US18277
申请日期
2005.05.25
申请人
BAYLOR COLLEGE OF MEDICINE;BOTAS, JUAN;RINCON-LIMAS, DIEGO;FERNANDEZ-FUNEZ, PEDRO;AL-RAMAHI, ISMAEL