| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a material for graft to be grafted to bone or cartilage defect parts for reproducing them in a shorter period of time in the treatment of a lesion accompanied by complicated and extensive bone or cartilage defects such as palatognathous disease and arthritis deformans, and a method for culturing anaplastic mesenchymal stem cells relating to its production. <P>SOLUTION: A gel forming material such as collagen, hyaluronic acid, the anaplastic mesenchymal stem cells, a buffer solution and an animal cell culture solution are mixed, made into a gel and turned to the material for the graft. The anaplastic mesenchymal stem cells embedded in the material for the graft increase while they are kept anaplastic under an environment without the presence of a differentiation inducing factor but differentiation to the bones and cartilages are more strongly induced compared to a control group not containing the hyaluronic acid under an environment in the presence of the differentiation inducing factor. <P>COPYRIGHT: (C)2006,JPO&NCIPI |
