发明名称 |
FIBULIN-3 AND USES THEREOF |
摘要 |
<p>Disclosed is a method and test kit to diagnose tumorigenicity or the presence of tumor cells in a patient by detecting the level of FBLN-3 expression or biological activity in the patient. Also disclosed are methods to identify regulators of tumor cell growth, motility and/or invasion, by identifying regulators of FBLN-3 expression or activity. Methods to identify anti-angiogenic and pro-angiogenic agents are also described, wherein such factors regulate the expression and/or activity of FBLN-3. Finally, the present invention relates to therapeutic methods and reagents for the inhibition of tumor growth and development and/or for the inhibition or promotion of angiogenesis, using FBLN-3, homologues and analogs thereof, and agents that modulate the expression and/or activity of FBLN-3.</p> |
申请公布号 |
WO2006052735(A2) |
申请公布日期 |
2006.05.18 |
申请号 |
WO2005US39976 |
申请日期 |
2005.11.04 |
申请人 |
NATIONAL JEWISH MEDICAL AND RESEARCH CENTER;SCHIEMANN, WILLIAM, P.;ALBIG, ALLAN, R. |
发明人 |
SCHIEMANN, WILLIAM, P.;ALBIG, ALLAN, R. |
分类号 |
C12Q1/68;A61K48/00;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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