| 摘要 |
<p>ÄProblemÜ To provide a composition having a steroid C17,20 lyase inhibitory activity and useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer. A compound represented by the formula: <CHEM> wherein R is a hydrogen atom or a protecting group, R<1> is a lower alkyl group or a cyclic hydrocarbon group, R<2> is an aromatic hydrocarbon group optionally having substituents or an aromatic heterocyclic group optionally having substituents, R<3> is a hydrocarbon group optionally having substituents, a hydroxyl group optionally having substituents, a thiol group optionally having substituents, an amino group optionally having substituents, an acyl group or a halogen atom, and n is an integer of 0 to 4, and a salt thereof have a steroid C17,20-lyase inhibitory activity, and are useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer and the like.</p> |
