BIOMATERIALS CARRYING CYCLODEXTRINES HAVING IMPROVED ABSORPTION PROPERTIES AND USED FOR THE PROGRESSIVE AND DELAYED RELEASE OF THERAPEUTIC MOLECULES

摘要

The invention relates to a method for preparing a biomaterial comprising at least one bioactive molecule from a base biomaterial. Said method is characterised by the following successive operations: a) a solid mixture of cyclodextrine(s) and/or cyclodextrine derivative(s) and/or cyclodextrine inclusion complex(es) and/or cyclodextrine derivatives, at least one poly(carboxylic) acid, and optionally a catalyst, is applied to the base biomaterial; and b) the base biomaterial and mixture are heated to a temperature of between 100 °C and 220 °C, for between 1 and 60 minutes; c) washed with water; and d) dried. The inventive method is also characterised in that at least one bioactive agent is incorporated into the biomaterial, by impregnating the biomaterial following the drying stage in a concentrated solution of a bioactive agent.