| 摘要 |
<p>Methods and compositions are provided for treating autoimmune diseases such as diabetes, rheumatoid arthritis, inflammatory bowel disease, and other conditions involving undesired immune responses such as allergies, including food allergies, and graft-versus-host disease. In one embodiment disclosed, regulatory / suppressor T cells are selected or expanded in culture using a phospholipase D (PLD) inhibitor to prevent growth of effector T cells and a growth factor to stimulate the regulatory cells. Antigen-specific regulatory / regulatory T cells can be produced by this method. The regulatory T cells can then be administered to a patient in need of suppressive immunotherapy. In another embodiment, PLD inhibitor, growth factor, and an antigen for which antigen-specific suppressive immunotherapy is desired are administered to a patient via injection, oral or topical administration, or other means known to the art.</p> |
