APPARATUS AND METHODS TO MEASURE OPTICAL ROTATION WITH ELECTRO-OPTIC POLARIZATION MODULATION

摘要

An optical rotation measuring apparatus including a light source positioned to transmit light through a first polarizer which is in optical communication with the light source. Also included is a sample cell suitable for holding a chiral compound for analysis. The sample cell is positioned to receive light transmitted through the first polarizer from the light source. The optical rotation measuring apparatus also includes an electro-optic modulator receiving light transmitted through the sample cell and an analyzer receiving light transmitted through the electro-optic modulator. In addition, the optical rotation measuring apparatus includes a photodetector receiving light transmitted through the analyzer. Another aspect of the present invention is a method of measuring optical rotation, including measuring optical rotation as a function of the amplitude of the intensity modulation of the light received by the photodetector.