发明名称 |
NUCLEOPHILIC SUBSTITUTION REACTIONS OF DIFLUOROMETHYL PHENYL SULFONE WITH ALKYL HALIDES LEADING TO THE FACILE SYNTHESIS OF TERMINAL 1,1-DIFLUORO-1-ALKENES AND DIFLUOROMETHYLALKANES |
摘要 |
(Benzenesulfonyl)difluoromethyl anion, in situ generated from difluoromethyl phenyl sulfone and a base, was found to easily undergo nucleophilic substitution reactions (S<SUB>N</SUB>2 with primary alkyl halides, elemental halogens, and perfluoroalkyl halides with good selectivity. The formed (Benzenesulfonyl) difluoromethylalkanes are useful intermediates for the facile preparation of 1,1-difluoro-1alkenes and difluoromethylalkanes. Thus, difluoromethyl phenyl sulfone acts as both "CF<SUB>2</SUB>=" and CF<SUB>2</SUB>H" synthons. |
申请公布号 |
WO2005097739(A3) |
申请公布日期 |
2006.05.18 |
申请号 |
WO2005US10225 |
申请日期 |
2005.03.25 |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA;PRAKASH, G.K., SURYA;HU, JINBO;OLAH, GEORGE, A.;WANG, YING |
发明人 |
PRAKASH, G.K., SURYA;HU, JINBO;OLAH, GEORGE, A.;WANG, YING |
分类号 |
C07C319/02;C07C17/361;C07C41/18;C07C43/225;C07C45/90;C07C315/04;C07C317/14;C07C317/18;C07C319/08 |
主分类号 |
C07C319/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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