LIPOSOME FORMULATION OF PEPTIDE BORONIC ACIDS COMPOUNDS

摘要

A liposome composition comprised of liposomes having a peptide boronic acid proteasome inhibitor compound entrapped in the liposome is described. The boronic acid compound is entrapped in the liposome in the form of a boronate ester, subsequent to interaction with a liposome-entrapped polyol. In one embodiment, the liposomes have an outer coating of hydrophilic polymer chains and are used to treat a malignancy in a subject.