发明名称 |
DEAMIDATED INTERFERON-BETA |
摘要 |
Interferon-.beta. protein analogs in which the asparagine at position 25, numbered in accordance with native interferon-.beta., is deamidated exhibit a biological activity of native human interferon-.beta. at an increased level and do not require HA for protein stabilization. The deamidated product is suitable for large scale manufacturing for incorporation in HA-containing or HA-free therapeutics for treatment of diseases including multiple sclerosis. An endoproteinase-C peptide map technique that produces a fingerprint profil e for proteins using an enzymatic digest followed by RP-HPLC is also useful in quality control as an ID and/or quantitative test for the deamidated product s.
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申请公布号 |
CA2587061(A1) |
申请公布日期 |
2006.05.18 |
申请号 |
CA20052587061 |
申请日期 |
2005.11.10 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS, INC. |
发明人 |
FURUYA, KENJI;JOHNSON-JACKSON, DEBORAH;RUSCIO, DIANA TIERRA |
分类号 |
C07K14/565;A61K38/19;A61P25/28 |
主分类号 |
C07K14/565 |
代理机构 |
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