发明名称 |
Akt and regulation of RA synovial fibroblast apoptosis |
摘要 |
The administration of an Akt inhibitor in a suitable carrier to a rheumatoid arthritis synovial fibroblast affords a process for inducing rheumatoid arthritis synovial fibroblast apoptosis. The Akt inhibitor is administered either as an active molecule or as a gene sequence expressible within rheumatoid arthritis synovial fibroblast cells. The gene sequence can be encompassed within a gene vector such as an adenovirus. A process for assaying rheumatoid arthritis drug candidates for apoptosis affect includes exposing a culture of rheumatoid arthritis synovial fibroblast cells to a drug candidate and monitoring apoptosis in the culture in the presence of the drug candidate. Apoptosis in the culture is compared to apoptosis induced in a duplicate culture in the presence of a known Akt inhibitor.
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申请公布号 |
US2006104951(A1) |
申请公布日期 |
2006.05.18 |
申请号 |
US20040989722 |
申请日期 |
2004.11.16 |
申请人 |
MOUNTZ JOHN D;ZHANG HUANG-GE;HSU HUI-CHEN |
发明人 |
MOUNTZ JOHN D.;ZHANG HUANG-GE;HSU HUI-CHEN |
分类号 |
A61K48/00;A61K31/366 |
主分类号 |
A61K48/00 |
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