Activators and inhibitors of protease activated receptor2 (PAR2) and methods of use

摘要

The present invention relates to a method of treating a subject for a condition mediated by a deficiency in angiogenesis by administering to the subject a PAR2 agonist under conditions effective to promote angiogenesis and treat the conditions mediated by a deficiency in angiogenesis. A further aspect of the present invention is a method of treating a subject for condition mediated by excessive or pathological angiogenesis by administering to the subject a PAR2 antagonist or inhibitor under conditions effective to inhibit angiogenesis and treat the subject for the condition mediated by excessive or pathological angiogenesis.