Recombinant TLR-MD-2 fusion proteins

摘要

The present invention provides recombinant TLR-MD-2 fusion proteins capable of binding to lipopolysaccharide (LPS) containing a TLR-moiety comprising the extracellular domain of a Toll-like receptor (TLR) or a functional derivative thereof, fused with a MD-2-moiety comprising MD-2 or a functional derivative thereof. In a preferred embodiment of the invention, the TLR-moiety and MD-2-moiety are fused via a flexible or inflexible linker and are provided with IgG-Fc and/or His-domains. The TLR-MD-2 fusion proteins of the present invention enable regulating of lipopolysaccharide (LPS) activity and modulating signaling of the Toll-like receptor (TLR) allowing an intervention in the septic process at its earliest state.