发明名称 |
MARKERS FOR IDENTIFICATION AND ISOLATION OF PANCREATIC ISLET ALPHA AND BETA CELL PROGENITORS |
摘要 |
<p>The differential expression of marker proteins in a targeted population provides a means of identifying and isolating cells. A population of cells associated with the regeneration of pancreatic islets is shown to express certain proteins, including the cell surface proteins ErbB2, ErbB3, and ErbB4; and the nuclear protein Msx-2. Populations of isolated pancreatic islet progenitor cells find use in screening assays, to characterize genes involved in islet development and regulation, and in transplantation to provide a recipient with pancreatic islet functions.</p> |
申请公布号 |
EP1240518(A4) |
申请公布日期 |
2006.05.17 |
申请号 |
EP20000984321 |
申请日期 |
2000.12.13 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
SARVETNICK, NORA;KRITZIK, MARCIE |
分类号 |
G01N33/48;A01K67/027;A61K35/12;A61L27/00;A61P3/10;C07K14/47;C07K14/705;C07K14/71;C12N5/074;C12N5/10;C12N15/85;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/569;G01N37/00;(IPC1-7):G01N33/566;C12N15/10;C12N5/08;C12N5/06 |
主分类号 |
G01N33/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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