| 摘要 |
<p>Using ethanol as plasticizer for preparing subcutaneous implants containing a dispersed active principle in a PLGA-based matrix by means of extrusion, the extrusion temperature, generally higher than 75 degree C, can be reduced to temperatures higher than the Tg of the PLGA, but lower than the boiling point of ethanol and therefore less than 70 degree C. In this manner subcutaneous implants containing thermolabile active principles, for example proteins, can be prepared.</p> |
