发明名称 |
PROCESS FOR PRODUCTION OF CIS-4-FLUORO-L-PROLINE DERIVATIVES |
摘要 |
<p>The present invention provides a safer method for production of a cis-4-fluoro-L-proline derivative under milder conditions and in good yield to give a product of high purity on an industrial scale at low cost. Namely, the present invention provides a method for producing a cis-4-fluoro-L-proline derivative, which comprises reacting a trans-4-hydroxy-L-proline derivative of the following Formula [I]:
(wherein R 1 represents a protecting group for an ±-amino group, and R 2 represents a protecting group for a carboxyl group) with N,N-diethyl-N-(1,1,2,3,3,3-hexafluoropropyl)amine in the presence of a hydrogen fluoride-scavenger.</p> |
申请公布号 |
EP1657237(A1) |
申请公布日期 |
2006.05.17 |
申请号 |
EP20040771788 |
申请日期 |
2004.08.18 |
申请人 |
TAISHO PHARMACEUTICAL CO. LTD. |
发明人 |
TOMISAWA, KAZUYUKI;TATSUTA, D.,;YOSHIDA, T.,;YOKOO, C., |
分类号 |
C07D207/16;(IPC1-7):C07D207/16 |
主分类号 |
C07D207/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|