The invention concerns derivatives of drosocin which have an increased half-life in mammalian serum by substituting one or more of the amino acid residues of wild type drosocin with another amino acid or a peptidomimetic moiety capable of replacing said amino acid. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition.
申请公布号
EP1657249(A1)
申请公布日期
2006.05.17
申请号
EP20040078089
申请日期
2004.11.10
申请人
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
发明人
VAN HOOFT, PETRUS ALBERTUS VENANTIA;NOORT, DANIEL;DE VISSER, PETER CHRISTIAN;OVERKLEEFT, HERMAN STEVEN;VAN BOOM, JACOBUS HUBERTUS