发明名称 Method for producing-2[-5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane
摘要 The present invention relates to a process for the preparation of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, the enantiomers and its salts, characterised in that 5-(4-fluorophenyl)pyridine-3-carbaldehyde is reacted directly with aminomethylchroman or its salts under reducing conditions to give 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, and the latter is, if desired, converted into one of its physiologically acceptable salts by treatment with an acid.
申请公布号 US7045629(B2) 申请公布日期 2006.05.16
申请号 US20030475988 申请日期 2003.10.27
申请人 MERCK PATENT GMBH 发明人 BOKEL HEINZ-HERMANN;NEUENFELD STEFFEN;GANTZERT LUDWIG;KNIERIEME RALF;SIMON ELKE;DEVANT RALF;HELM UDO;REUBOLD HELMUT
分类号 C07D401/00;C07D311/58;C07D405/12 主分类号 C07D401/00
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