发明名称 |
MITTEL ZUR VERMINDERUNG VON NEBENEFFEKTEN |
摘要 |
<p>The present invention provides an agent for alleviating side effects caused by use of an anti-tumor agent, which contains 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidi nedione (1) represented by formula (1): <CHEM> or a pharmaceutically acceptable salt thereof. The 5-chloro -6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione or a pharmaceutically acceptable salt thereof exhibit an inflammatory-suppressing action in the digestive tract and advantageously alleviate diarrhea and loss of body weight concomitant with administration of a chemical for treating cancer without suppressing the anti-tumor effect. Thus, the compounds of the present invention are of great value as agents for alleviating side effects caused by use of an anti-tumor agent, which enable not only the chemotherapy to be continuedly carried out, but also the body exhaustion to be effectively prevented.</p> |
申请公布号 |
AT323494(T) |
申请公布日期 |
2006.05.15 |
申请号 |
AT20000909678T |
申请日期 |
2000.03.16 |
申请人 |
TAIHO PHARMACEUTICAL COMPANY LIMITED |
发明人 |
FUKUSHIMA, MASAKAZU;YAMAMOTO, NORIYUKI;SUZUKI, NORIHIKO |
分类号 |
C07D239/30;A61K31/00;A61K31/28;A61K31/282;A61K31/47;A61K31/4738;A61K31/4745;A61K31/505;A61K31/506;A61K31/513;A61K31/70;A61K31/7042;A61K31/7052;A61K31/706;A61K31/7064;A61K31/7068;A61K31/7072;A61P1/08;A61P1/12;A61P3/00;A61P35/00;A61P39/00;A61P43/00;C07D403/06;C07D491/22;C07H19/073;(IPC1-7):A61K31/513 |
主分类号 |
C07D239/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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