| 摘要 |
<p>Gold (I) compounds simultaneously coordinated by mono- and biden- tate phosphines having the following formulas: (A) and (B) wherein R<1>, R<2>, R<3>, = methyl, ethyl, propyl, butyl, phenyl, <i>p</i>-tolyl, <i>m</i>-tolyl, <i>o</i>-tolyl, mesityl, cyclohexyl or benzyl; R<a>, R<b> = methyl, ethyl, phenyl or cyclohexyl; n = 1-5; X = Cl or Br; or (C) wherein R<1>, R<2>, R<3>, R<a>, R<b> are as for formulas (A) and (B); Z = (CH2)n with n = 1-5, or Z = 4,4'-ferrocenyl; X = Br, I, NO3 or CIO4. The compounds are active as tumor cell growth-inhibiting agents and are suitable for use in anti-tumor pharmaceutical compositions. The invention also relates to methods for synthesizing gold-phosphine compounds of formulas (A), (B) and (C).</p> |
