USE OF CYCLIC BIOISOSTERES OF PURINE SYSTEM DERIVATIVES FOR THE TREATMENT OF DISEASES CAUSED BY DISORDERS OF NITRERGIC AND DOPAMINERGIC SYSTEMS

摘要

The invention relates to application of compounds having a general structural formula:
where R=
Li, Na, K,
R 1 = -H, -NH 2 , -Br, -Cl, -OH, -COOH,
B = -N=, -CH=, Z = -CH= , -N=,
A = -N= at B = -N= , Z = -CH-,
A=-CH= at B = -N= , Z=-CH-,
A = -CH= at B = -N= , Z = -N=,
A = -CH= at B = -CH= , Z = -CH=,
A = -CH= at B = -CH= , Z = -N= ,
and/or their pharmacologically acceptable salts as an active ingredient having appropriate activity with respect to nitrergic and/or dopaminergic systems, in a pharmaceutical composition as neuroprotector for improvement of the cognitive function and for normalization of psychophysiological status, as well as for treatment of a wide spectrum of psychological diseases, cardiovascular diseases, diseases caused by substance abuse, and diseases caused by a hyperactive immune system in mammals including human beings.