| 摘要 |
<p>(A) 2-Phenoxy-2-phenylacetamides (I) A= (2-7C) alkylene, with at least 2 consecutive C atoms separating the N atoms. R1 & R2 = (1-6C) alkyl or (is not >6C) cycloalkyl, or together = (4-9C) alkylene, with 4 or 5 atoms forming a ring together with N. (B) Acid addn. salts of (I) a) Anti-arrhythmics b) Intermediates 2-phenoxy-2-phenylacetic acid ethyl esster (25.6g) and 5-(2,6-dimethylpiperidino) pentylamine (19.8g) were heated 22hr. at 150-160 deg., cooled, dissolved in PhMe, and extd. with d.HCl. Extract basified (NaOH), extd. with PhMe, dried, filtered, evapd. in vac., and recryst from Ph-Me/Petrol, giving I, m.p. 100-2 deg.</p> |
