发明名称 |
ATOPIC DERMATITIS INDUCER |
摘要 |
An atopic dermatitis inducer binding to a human own IgE antibody and activating mast cells and basophiles, which includes a purified human secretion fraction, or an antigenic molecule or an antigenic determinant in the purified fraction, and obtained through the following steps of: filtering a human secretion, removing insoluble matters and collecting the filtrate; mixing the filtrate with a ConA-affinity carrier and collecting the supernatant; and separating a component having a histamine-releasing activity from the supernatant by column chromatography. This inducer is effective in diagnosing and treating human atopic dermatitis.
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申请公布号 |
EP1655307(A1) |
申请公布日期 |
2006.05.10 |
申请号 |
EP20040747610 |
申请日期 |
2004.07.09 |
申请人 |
SHIONOGI & CO., LTD. |
发明人 |
HIDE, MICHIHIRO;TANAKA, TOSHIHIKO;TANAKA, AKIO;ISHII, KAORI;SUZUKI, HIDENORI |
分类号 |
C07K14/47;A61P37/08;C07K16/42;G01N33/68;(IPC1-7):C07K14/47;C07K16/18;A61K49/00 |
主分类号 |
C07K14/47 |
代理机构 |
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