具有抗微生物活性的模板固定化肽模拟物

摘要

具有通式(I)和(II)的模板固定化β-发夹肽模拟物及其盐其中Z、Z¹和Z²是8-16个α-氨基酸残基的模板固定化链，根据这些氨基酸残基在链中的位置(从N-末端氨基酸开始数)，它们是Gly或Pro或某些类型，上式中的剩余符号，定义如本说明书和权利要求书中所述，该肽模拟物及其盐具有抑制微生物和癌细胞生长或将其杀死的性能。它们可用作食品、化妆品、药品或其它含营养素的物品的消毒剂，或者作为治疗或预防感染或与这些感染和/或癌症有关的疾病的药物。这些β-发夹肽模拟物可以通过一种基于混合固体-和溶液相协同的方法生产。

主权项

1、下面通式的化合物及其药用可接受的盐和其中是下式基团之一其中是B是式-NR²⁰CH(R⁷¹)-或本文后面定义的基团A1-A69之一的对映异构体的残基的L-α-氨基酸的残基；是以下基团之一R¹是H；低级烷基或芳基-低级烷基；R²是H；烷基；链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sSR⁵⁶；-(CH₂)_m(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_m(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R³是H；烷基；链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sSR⁵⁶；-(CH₂)_m(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_m(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R⁴是H；烷基；链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sSR⁵⁶；-(CH₂)_m(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_m(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_p(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_p(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_p(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_p(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R⁵是烷基；链烯基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R⁶是H；烷基；链烯基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R⁷是烷基；链烯基；-(CH₂)_q(CHR⁶¹)_sOR⁵⁵；-(CH₂)_q(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_q(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_q(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_r(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_r(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_r(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_r(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_r(CHR⁶¹)_sC₆H₄R⁸；R⁸是H；Cl；F；CF₃；NO₂；低级烷基；低级链烯基；芳基；芳基-低级烷基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)NR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sCOR⁶⁴；R⁹是烷基；链烯基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R¹⁰是烷基；链烯基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R¹¹是H；烷基；链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_m(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R¹²是H；烷基；链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sSR⁵⁶；-(CH₂)_m(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_m(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_r(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_r(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_r(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_r(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_r(CHR⁶¹)_sC₆H₄R⁸；R¹³是烷基；链烯基；-(CH₂)_q(CHR⁶¹)_sOR⁵⁵；-(CH₂)_q(CHR⁶¹)_sSR⁵⁶；-(CH₂)_q(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_q(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_q(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_q(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_q(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_q(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_q(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_q(CHR⁶¹)_sC₆H₄R⁸；R¹⁴是H；烷基；链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_m(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_q(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_q(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_q(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_q(CHR⁶¹)_sSOR⁶²或-(CH₂)_q(CHR⁶¹)_sC₆H₄R⁸；R¹⁵是烷基；链烯基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R¹⁶是烷基；链烯基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R¹⁷是烷基；链烯基；-(CH₂)_q(CHR⁶¹)_sOR⁵⁵；-(CH₂)_q(CHR⁶¹)_sSR⁵⁶；-(CH₂)_q(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_q(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_q(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_q(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_q(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_q(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_q(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_q(CHR⁶¹)_sC₆H₄R⁸；R¹⁸是烷基；链烯基；-(CH₂)_p(CHR⁶¹)_sOR⁵⁵；-(CH₂)_p(CHR⁶¹)_sSR⁵⁶；-(CH₂)_p(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_p(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH²)_p(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_p(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_p(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_p(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_p(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R¹⁹是低级烷基；-(CH₂)_p(CHR⁶¹)_sOR⁵⁵；-(CH₂)_p(CHR⁶¹)_sSR⁵⁶；-(CH₂)_p(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_p(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_p(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_p(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_p(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_p(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_p(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸或R¹⁸和R¹⁹一起可以形成：-(CH₂)_2-6-；-(CH₂)₂O(CH₂)₂-；-(CH₂)₂S(CH₂)₂-或-(CH₂)₂NR⁵⁷(CH₂)₂-；R²⁰是H；烷基；链烯基或芳基-低级烷基；R²¹是H；烷基；链烯基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R²²是H；烷基；链烯基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R²³是烷基；链烯基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R²⁴是烷基；链烯基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R²⁵是H；烷基；链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sSR⁵⁶；-(CH₂)_m(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_m(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R²⁶是H；烷基；链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sSR⁵⁶；-(CH₂)_m(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_m(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸或R²⁵和R²⁶一起可以形成：-(CH₂)_2-6-；-(CH₂)_rO(CH₂)_r-；-(CH₂)_rS(CH₂)_r-或-(CH₂)_rNR⁵⁷(CH₂)_r-；R²⁷是H；烷基；链烯基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R²⁸是烷基；链烯基；-(CH₂)_o(CHR⁶¹)_s-OR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R²⁹是烷基；链烯基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R³⁰是H；烷基；链烯基或芳基-低级烷基；R³¹是H；烷基；链烯基；-(CH₂)_p(CHR⁶¹)_sOR⁵⁵；-(CH₂)_p(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_p(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_p(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R³²是H；低级烷基或芳基-低级烷基；R³³是H；烷基，链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sNR³⁴R⁶³；-(CH₂)_m(CHR⁶¹)_sOCONR⁷⁵R⁸²；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR⁷⁸R⁸²；-(CH₂)_o(CHR⁶¹)_sCOR⁶⁴；-(CH₂)_o(CHR⁶¹)_s-CONR⁵⁸R⁵⁹，-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R³⁴是H；低级烷基；芳基或芳基-低级烷基；R³³和R³⁴一起可以形成：-(CH₂)_2-6-；-(CH₂)₂O(CH₂)₂-；-(CH₂)₂S(CH₂)₂-或-(CH₂)₂NR⁵⁷(CH₂)₂-；R³⁵是H；烷基；链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_m(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_p(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_p(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_p(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_p(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_p(CHR⁶¹)_sC₆H₄R⁸；R³⁶是H，烷基；链烯基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_p(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_p(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_p(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_p(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_p(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_p(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_p(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R³⁷是H；F；Br；Cl；NO₂；CF₃；低级烷基；-(CH₂)_p(CHR⁶¹)_sOR⁵⁵；-(CH₂)_p(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_p(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_p(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R³⁸是H；F；Br；Cl；NO₂；CF₃；烷基；链烯基；-(CH₂)_p(CHR⁶¹)_sOR⁵⁵；-(CH₂)_p(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_p(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_p(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R³⁹是H；烷基；链烯基或芳基-低级烷基；R⁴⁰是H；烷基；链烯基或芳基-低级烷基；R⁴¹是H；F；Br；Cl；NO₂；CF₃；烷基；链烯基；-(CH₂)_p(CHR⁶¹)_sOR⁵⁵；-(CH₂)_p(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_p(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_p(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R⁴²是H；F；Br；Cl；NO₂；CF₃；烷基；链烯基；-(CH₂)_p(CHR⁶¹)_sOR⁵⁵；-(CH₂)_p(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_p(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_p(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R⁴³是H；烷基；链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_m(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_o(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R⁴⁴是烷基；链烯基；-(CH₂)_r(CHR⁶¹)_sOR⁵⁵；-(CH₂)_r(CHR⁶¹)_sSR⁵⁶；-(CH₂)_r(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_r(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_r(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_r(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_r(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_r(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_r(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_r(CHR⁶¹)_sC₆H₄R⁸；R⁴⁵是H；烷基；链烯基；-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；-(CH₂)_o(CHR⁶¹)_sSR⁵⁶；-(CH₂)_o(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_o(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_o(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_s(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_s(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CH₂)_s(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_s(CHR⁶¹)_sC₆H₄R⁸；R⁴⁶是H；烷基；链烯基或-(CH₂)_o(CHR⁶¹)_pC₆H₄R⁸；R⁴⁷是H；烷基；链烯基或-(CH₂)_o(CHR⁶¹)_sOR⁵⁵；R⁴⁸是H；低级烷基；低级链烯基或芳基-低级烷基；R⁴⁹是H；烷基；链烯基；-(CHR⁶¹)_sCOOR⁵⁷；(CHR⁶¹)_sCONR⁵⁸R⁵⁹；(CHR⁶¹)_sPO(OR⁶⁰)₂；-(CHR⁶¹)_sSOR⁶²或-(CHR⁶¹)_sC₆H₄R⁸；R⁵⁰是H；低级烷基或芳基-低级烷基；R⁵¹是H；烷基；链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sSR⁵⁶；-(CH₂)_m(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_m(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_pPO(OR⁶⁰)₂；-(CH₂)_p(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_p(CHR⁶¹)_sC₆H₄R⁸；R⁵²是H；烷基；链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sSR⁵⁶；-(CH₂)_m(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_m(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_pPO(OR⁶⁰)₂；-(CH₂)_p(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_p(CHR⁶¹)_sC₆H₄R⁸；R⁵³是H；烷基；链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sSR⁵⁶；-(CH₂)_m(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_m(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；-(CH₂)_o(CHR⁶¹)_pPO(OR⁶⁰)₂；-(CH₂)_p(CHR⁶¹)_sSO₂R⁶²或-(CH₂)_p(CHR⁶¹)_sC₆H₄R⁸；R⁵⁴是H；烷基；链烯基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁵；-(CH₂)_m(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_m(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)COOR⁵⁷；-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹或-(CH₂)_o(CHR⁶¹)_sC₆H₄R⁸；R⁵⁵是H；低级烷基；低级链烯基；芳基-低级烷基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁷；-(CH₂)_m(CHR⁶¹)_sNR³⁴R⁶³；-(CH₂)_m(CHR⁶¹)_sOCONR⁷⁵R⁸²；-(CH₂)_m(CHR⁶¹)_sNR²⁰CONR⁷⁸R⁸²；-(CH₂)_o(CHR⁶¹)_s-COR⁶⁴；-(CH₂)_o(CHR⁶¹)COOR⁵⁷或-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；R⁵⁶是H；低级烷基；低级链烯基；芳基-低级烷基；-(CH₂)_m(CHR⁶¹)_sOR⁵⁷；-(CH₂)_m(CHR⁶¹)_sNR³⁴R⁶³；-(CH₂)_m(CHR⁶¹)_sOCONR⁷⁵R⁸²；-(CH²)_m(CHR⁶¹)_sNR²⁰CONR⁷⁸R⁸²；-(CH₂)_o(CHR⁶¹)_s-COR⁶⁴或-(CH₂)_o(CHR⁶¹)_sCONR⁵⁸R⁵⁹；R⁵⁷是H；低级烷基；低级链烯基；芳基-低级烷基或杂芳基-低级烷基；R⁵⁸是H；低级烷基；低级链烯基；芳基；杂芳基；芳基-低级烷基或杂芳基-低级烷基；R⁵⁹是H；低级烷基；低级链烯基；芳基；杂芳基；芳基-低级烷基或杂芳基-低级烷基或R⁵⁸和R⁵⁹一起可以形成：-(CH₂)_2-6-；-(CH₂)₂O(CH₂)₂-；-(CH₂)₂S(CH₂)₂-或-(CH₂)₂NR⁵⁷(CH₂)₂-；R⁶⁰是H；低级烷基；低级链烯基；芳基或芳基-低级烷基；R⁶¹是烷基；链烯基；芳基；杂芳基；芳基-低级烷基；杂芳基-低级烷基；-(CH₂)_mOR⁵⁵；-(CH₂)_mNR³³R³⁴；-(CH₂)_mOCONR⁷⁵R⁸²；-(CH₂)_mNR²⁰CONR⁷⁸R⁸²；-(CH₂)_oCOOR³⁷；-(CH₂)_oNR⁵⁸R⁵⁹或-(CH₂)_oPO(COR⁶⁰)₂；R⁶²是低级烷基；低级链烯基；芳基，杂芳基或芳基-低级烷基；R⁶³是H；低级烷基；低级链烯基；芳基，杂芳基；芳基-低级烷基；杂芳基-低级烷基；-COR⁶⁴；-COOR⁵⁷；-CONR⁵⁸R⁵⁹；-SO₂R⁶²或-PO(OR⁶⁰)₂；R³⁴和R⁵³一起可以形成：-(CH₂)_2-6-；-(CH₂)₂O(CH₂)₂-；-(CH₂)₂S(CH₂)₂-或-(CH₂)₂NR⁵⁷(CH₂)₂-；R⁶⁴是H；低级烷基；低级链烯基；芳基；杂芳基；芳基-低级烷基；杂芳基-低级烷基；-(CH₂)_p(CHR⁶¹)_sOR⁶⁵；-(CH₂)_p(CHR⁶¹)_sSR⁶⁶或-(CH₂)_p(CHR⁶¹)_sNR³⁴R⁶³；-(CH₂)_p(CHR⁶¹)_sOCONR⁷⁵R⁸²；-(CH₂)_P(CHR⁶¹)_sNR²⁰CONR⁷⁸R⁸²；R⁶⁵是H；低级烷基；低级链烯基；芳基，芳基-低级烷基；杂芳基-低级烷基；-COR⁵⁷；-COOR⁵⁷或-CONR⁵⁸R⁵⁹；R⁶⁶是H；低级烷基；低级链烯基；芳基；芳基-低级烷基；杂芳基-低级烷基或-CONR⁵⁸R⁵⁹；m是2-4；o是0-4；p是1-4；q是0-2；r是1或2；s是0或1；和独立地具有上面定义的任何含义除了B是-NR²⁰CH(R⁷¹)-和A是A80、A81、A90、A91、A95或A96的(a1)或(a2)之外，并且除(f)和(m)之外，但是其中R²是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sS-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R³是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sS-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R⁴是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sS-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_p(CHR⁶¹)_sCO-；R⁵是-(CH₂)_o(CHR⁶¹)_sO-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R⁶是-(CH₂)_o(CHR⁶¹)_sO-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R⁷是-(CH₂)_q(CHR⁶¹)_sO-；-(CH₂)_q(CHR⁶¹)_sNR³⁴-或-(CH₂)_r(CHR⁶¹)_sCO-；R⁸是-(CH₂)_o(CHR⁶¹)_sO-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R⁹是-(CH₂)_o(CHR⁶¹)_sO-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R¹⁰是-(CH₂)_o(CHR⁶¹)_sO-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R¹¹是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R¹²是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_r(CHR⁶¹)_sCO-；R¹³是-(CH₂)_q(CHR⁶¹)_sO-；-(CH₂)_q(CHR⁶¹)_sS-；-(CH₂)_q(CHR⁶¹)_sNR³⁴-或-(CH₂)_q(CHR⁶¹)_sCO-；R¹⁴是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_q(CHR⁶¹)_sCO-；R¹⁵是-(CH₂)_o(CHR⁶¹)_sO-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R¹⁶是-(CH₂)_o(CHR⁶¹)_sO-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R¹⁷是-(CH₂)_q(CHR⁶¹)_sO-；-(CH₂)_q(CHR⁶¹)_sS-；-(CH₂)_q(CHR⁶¹)_sNR³⁴-或-(CH₂)_q(CHR⁶¹)_sCO-；R¹⁸是-(CH₂)_p(CHR⁶¹)_sO-；-(CH₂)_p(CHR⁶¹)_sS-；-(CH₂)_p(CHR⁶¹)_sNR³⁴-或-(CH₂)_p(CHR⁶¹)_sCO-；R¹⁹是-(CH₂)_p(CHR⁶¹)_sO-；-(CH₂)_p(CHR⁶¹)_sS-；-(CH₂)_p(CHR⁶¹)_sNR³⁴-或-(CH₂)_p(CHR⁶¹)_sCO-；R²¹是-(CH₂)_o(CHR⁶¹)_sO-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R²²是-(CH₂)_o(CHR⁶¹)_sO-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R²³是-(CH₂)_o(CHR⁶¹)_sO-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R²⁴是-(CH₂)_o(CHR⁶¹)_sO-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R²⁵是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sS-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R²⁶是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sS-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R²⁷是-(CH₂)_o(CHR⁶¹)_sO-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R²⁸是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sS-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R²⁹是-(CH₂)_o(CHR⁶¹)_sO-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R³¹是-(CH₂)_p(CHR⁶¹)_sO-；-(CH₂)_p(CHR⁶¹)_sS-；-(CH₂)_p(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R³³是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R³⁷是-(CH₂)_p(CHR⁶¹)_sO-；-(CH₂)_p(CHR⁶¹)_sS-；-(CH₂)_p(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R³⁸是-(CH₂)_p(CHR⁶¹)_sO-；-(CH₂)_p(CHR⁶¹)_sS-；-(CH₂)_p(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R⁴¹是-(CH₂)_p(CHR⁶¹)_sO-；-(CH₂)_p(CHR⁶¹)_sS-；-(CH₂)_p(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R⁴²是-(CH₂)_p(CHR⁶¹)_sO-；-(CH₂)_p(CHR⁶¹)_sS-；-(CH₂)_p(CHR⁶¹)_sNR³⁴-^-或-(CH₂)_o(CHR⁶¹)_sCO-；R⁴³是-(CH₂)_m(CHR⁶¹)_sO；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R⁴⁵是-(CH₂)_o(CHR⁶¹)_sO-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sNR³⁴-或-(CH₂)_s(CHR⁶¹)_sCO-；R⁴⁷是-(CH₂)_o(CHR⁶¹)_sO-；R⁴⁹是-(CHR⁶¹)_sO-；-(CHR⁶¹)_sS-；-(CHR⁶¹)_sNR³⁴-或-(CHR⁶¹)_sCO-；R⁵¹是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sS-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R⁵²是-(CH₂)_m(CHR⁵¹)_sO-；-(CH₂)_m(CHR⁶¹)_sS-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R⁵³是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sS-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R⁵⁴是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R⁵⁵是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R⁵⁶是-(CH₂)_m(CHR⁶¹)_sO-；-(CH₂)_m(CHR⁶¹)_sNR³⁴-或-(CH₂)_o(CHR⁶¹)_sCO-；R⁶⁴是-(CH₂)_p(CHR⁶¹)_sO-；-(CH₂)_p(CHR⁶¹)_sS-或-(CH₂)_p(CHR⁶¹)_sNR³⁴-；m、o、p、q、r和s定义如上；前提是如果存在一个以上的取代基R²-R¹⁹、R²¹ to R²⁹、R³¹、R³³、R³⁷、R³⁸、R⁴¹ to R⁴³、R⁴⁵、R⁴⁷、R⁴⁹、R⁵¹ to R⁵⁶和R⁶⁴，那么它们中间仅一个具有刚才提到的含义，而其它取代基具有前面提到的任何含义；L是一直接键或这些接头中的一个L1：-(CH₂)_pCHR⁶¹[X(CH₂)pCHR⁶¹]_o-；L2：-CO(CH₂)_pCHR⁶¹[X(CH₂)pCHR⁶¹]_oCO-；L3：-CONR³⁴(CH₂)_pCHR⁶¹[X(CH₂)pCHR⁶¹]_oNR³⁴CO-；L4：-O(CH₂)_pCHR⁶¹[X(CH₂)pCHR⁶¹]_oO-；L5：-S(CH₂)_pCHR⁶¹[X(CH₂)pCHR⁶¹]_oS-；L6：-NR³⁴(CH₂)_pCHR⁶¹[X(CH₂)pCHR⁶¹]_oNR³⁴-；L7：-(CH₂)_oCHR⁶¹Y(CH₂)_oCHR⁶¹-；L8：-CO(CH₂)_oCHR⁶¹Y(CH₂)_oCHR⁶¹CO-；L9：-CONR³⁴(CH₂)_oCHR⁶¹Y(CH₂)_oCHR⁶¹NR³⁴CO-；L10：-O(CH₂)_oCHR⁶¹Y(CH₂)_oCHR⁶¹O-；L11：-S(CH₂)_oCHR⁶¹Y(CH₂)_oCHR⁶¹S-；L12：-NR³⁴(CH₂)_oCHR⁶¹Y(CH₂)_oCHR⁶¹NR³⁴-；L13：-CO(CH₂)_pCHR⁶¹[X(CH₂)pCHR⁶¹]_oNR³⁴-；L14：-CO(CH₂)_oCHR⁶¹Y(CH₂)_oCHR⁶¹NR³⁴-；L15  -NR³⁴(CH₂)_pCHR⁶¹[X(CH₂)pCHR⁶¹]_oCO-；和L16  -NR³⁴(CH₂)_oCHR⁶¹Y(CH₂)_oCHR⁶¹CO-；m、o、p、q、r和s定义如上；X是O；S；NR³⁴；-NR³²CONR³⁴-或-OCOO-；和Y是-C₆R⁶⁷R⁶⁸R⁶⁹R⁷⁰-；R⁶⁷是H；Cl；Br；F；NO₂；-NR³⁴COR⁵⁷；低级烷基或低级链烯基；R⁶⁸是H；Cl；Br；F；NO₂；-NR³⁴COR⁵⁷；低级烷基或低级链烯基；R⁶⁹是H；Cl；Br；F；NO₂；-NR³⁴COR⁵⁷；低级烷基或低级链烯基；和R⁷⁰是H；Cl；Br；F；NO₂；-NR³⁴COR⁵⁷；低级烷基或低级链烯基；前提是R⁶⁷、R⁶⁸、R⁶⁹和R⁷⁰中至少两个是H；和其它前提是-(CH₂)_m(CHR⁶¹)_sO-可以与接头L1、L2、L3、L7、L8或L9结合；-(CH₂)_o(CHR⁶¹)_sO-可以与接头L1、L2、L3、L7、L8或L9结合；-(CH₂)_p(CHR⁶¹)_sO-可以与接头L1、L2、L3、L7、L8或L9结合；-(CH₂)_q(CHR⁶¹)_sO-可以与接头L1、L2、L3、L7、L8或L9结合；-(CHR⁶¹)_sO-可以与接头L1、L2、L3、L7、L8或L9结合；-(CH₂)_m(CHR⁶¹)_sS-可以与接头L1、L2、L3、L7、L8或L9结合或者可以与-(CH₂)_m(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_p(CHR⁶¹)_sS-；-(CH₂)_q(CHR⁶¹)_sS-或-(CHR⁶¹)_sS-形成二硫键；-(CH₂)_o(CHR⁶¹)_sS-可以与接头L1、L2、L3、L7、L8或L9结合或者可以与-(CH₂)_m(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_p(CHR⁶¹)_sS-；-(CH₂)_q(CHR⁶¹)_sS-或-(CHR⁶¹)_sS-形成二硫键；-(CH₂)_p(CHR⁶¹)_sS-可以与接头L1、L2、L3、L7、L8或L9结合或者可以与-(CH₂)_m(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_p(CHR⁶¹)_sS-；-(CH₂)_q(CHR⁶¹)_sS-或-(CHR⁶¹)_sS-形成二硫键；-(CH₂)_q(CHR⁶¹)_sS-可以与接头L1、L2、L3、L7、L8或L9结合或者可以与-(CH₂)_m(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_p(CHR⁶¹)_sS-；-(CH₂)_q(CHR⁶¹)_sS-或-(CHR⁶¹)_sS-形成二硫键；-(CHR⁶¹)_sS-可以与接头L1、L2、L3、L7、L8或L9结合或者可以与-(CH₂)_m(CHR⁶¹)_sS-；-(CH₂)_o(CHR⁶¹)_sS-；-(CH₂)_p(CHR⁶¹)_sS-；-(CH₂)_q(CHR⁶¹)_sS-或-(CHR⁶¹)_sS-形成二硫键；-(CH₂)_m(CHR⁶¹)_sNR³⁴-可以与接头L1、L2、L3、L7、L8或L9结合；-(CH₂)_o(CHR⁶¹)_sNR³⁴-可以与接头L1、L2、L3、L7、L8或L9结合；-(CH₂)_p(CHR⁶¹)_sNR³⁴-可以与接头L1、L2、L3、L7、L8或L9结合；-(CH₂)_q(CHR⁶¹)_sNR³⁴-可以与接头L1、L2、L3、L7、L8或L9结合；-(CHR⁶¹)_sNR³⁴-可以与接头L1、L2、L3、L7、L8或L9结合；-(CH₂)_o(CHR⁶¹)_sCO-可以与接头L4、L5、L6、L10、L11或L12结合；-(CH₂)_p(CHR⁶¹)_sCO-可以与接头L4、L5、L6、L10、L11或L12结合；-(CH₂)_q(CHR⁶¹)_sCO-可以与接头L4、L5、L6、L10、L11或L12结合；-(CH₂)_r(CHR⁶¹)_sCO-可以与接头L4、L5、L6、L10、L11或L12结合；-(CHR⁶¹)_sCO-可以与接头L4、L5、L6、L10、L11或L12结合；-(CH₂)_m(CHR⁶¹)_sO-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_m(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CH₂)_o(CHR⁶¹)_sO-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_o(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CH₂)_p(CHR⁶¹)_sO-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_o(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CH₂)_q(CHR⁶¹)_sO-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_o(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CHR⁶¹)_sO-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_o(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CH₂)_m(CHR⁶¹)_sS-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_o(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CH₂)_o(CHR⁶¹)_sS-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_o(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CH₂)_p(CHR⁶¹)_sS-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_o(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CH₂)_q(CHR⁶¹)_sS-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_o(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CHR₆₁)_sS-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_o(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CH₂)_m(CHR⁶¹)_sNR³⁴-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_o(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CH₂)_o(CHR⁶¹)_sNR³⁴-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_o(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CH₂)_p(CHR⁶¹)_sNR³⁴-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_o(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CH₂)_q(CHR⁶¹)_sNR³⁴-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_o(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CHR⁶¹)_sNR³⁴-可以与接头L13或L14结合并且所得结合物可以与-(CH₂)_o(CHR⁶¹)_sCO-；-(CH₂)_o(CHR⁶¹)_pCO-；-(CH₂)_q(CHR⁶¹)_sCO-或-(CHR⁶¹)_sCO-结合；-(CH₂)_o(CHR⁶¹)_sCO-可以与L15或L16结合并且所得结合物可以与-(CH₂)_m(CHR⁶¹)_sX-、-(CH₂)_o(CHR⁶¹)_sX-、-(CH₂)_p(CHR⁶¹)_sX-、-(CH₂)_q(CHR⁶¹)_sX-或-(CHR⁶¹)_sX-结合；-(CH₂)_p(CHR⁶¹)_sCO-可以与L15或L16结合并且所得结合物可以与-(CH₂)_m(CHR⁶¹)_sX-、-(CH₂)_o(CHR⁶¹)_sX-、-(CH₂)_p(CHR⁶¹)_sX-、-(CH₂)_q(CHR⁶¹)_sX-或-(CHR⁶¹)_sX-结合；-(CH₂)_q(CHR⁶¹)_sCO-可以与L15或L16结合并且所得结合物可以与-(CH₂)_m(CHR⁶¹)_sX-、-(CH₂)_o(CHR⁶¹)_sX-、-(CH₂)_p(CHR⁶¹)_sX-、-(CH₂)_q(CHR⁶¹)_sX-或-(CHR⁶¹)_sX-结合；-(CH₂)_r(CHR⁶¹)_sCO-可以与L15或L16结合并且所得结合物可以与-(CH₂)_m(CHR⁶¹)_sX-、-(CH₂)_o(CHR⁶¹)_sX-、-(CH₂)_p(CHR⁶¹)_sX-、-(CH₂)_q(CHR⁶¹)_sX-或-(CHR⁶¹)_sX-结合；-(CHR⁶¹)_sCO-可以与L15或L16结合并且所得结合物可以与-(CH₂)_m(CHR⁶¹)_sX-、-(CH₂)_o(CHR⁶¹)_sX-、-(CH₂)_p(CHR⁶¹)_sX-、-(CH₂)_q(CHR⁶¹)_sX-或-(CHR⁶¹)_sX-结合；Z、Z¹和Z²独立地是n个α-氨基酸残基的链，n是整数8-16，所述氨基酸残基在所述链中的位置是从N-末端氨基酸开始计数的，由此这些氨基酸残基，根据它们在链中的位置，是Gly或Pro，Z、Z¹和Z²或者是式-A-CO-的链，或者是式-B-CO-的链，或者是以下类型之一的链C：-NR²⁰CH(R⁷²)CO-；D：-NR²⁰CH(R⁷³)CO-；E：-NR²⁰CH(R⁷⁴)CO-；F：-NR²⁰CH(R⁸⁴)CO-；和H：-NR²⁰-CH(CO-)-(CH₂)_4-7-CH(CO-)-NR²⁰-；-NR²⁰-CH(CO-)-(CH₂)_pSS(CH₂)_p-CH(CO-)-NR²⁰-；-NR²⁰-CH(CO-)-(-(CH₂)_pNR²⁰CO(CH₂)_p-CH(CO-)-NR²⁰-；和-NR²⁰-CH(CO-)-(-(CH₂)_pNR²⁰CONR²⁰(CH₂)_p-CH(CO-)-NR²⁰-；R⁷¹是H；低级烷基；低级链烯基；-(CH₂)_p(CHR⁶¹)_sOR⁷⁵；-(CH₂)_p(CHR⁶¹)_sSR⁷⁵；-(CH₂)_p(CHR⁶¹)_sNR³³R³⁴；-(CH₂)_p(CHR⁶¹)_sOCONR³³R⁷⁵；-(CH₂)_p(CHR⁶¹)_sNR²⁰CONR³³R⁸²；-(CH₂)_o(CHR⁶¹)_sCOOR⁷⁵；-(CH₂)_pCONR⁵⁸R⁵⁹；-(CH₂)_pPO(OR⁶²)₂；-(CH₂)_pSO₂R⁶²或-(CH₂)_o-C₆R⁶⁷R⁶⁸R⁶⁹R⁷⁰R⁷⁶；R⁷²是H；低级烷基；低级链烯基；-(CH₂)_p(CHR⁶¹)_sOR⁸⁵或-(CH₂)_p(CHR⁶¹)_sSR⁸⁵；R⁷³是-(CH₂)_oR⁷⁷；-(CH₂)_rO(CH₂)_oR⁷⁷；-(CH₂)_rS(CH₂)_oR⁷⁷或-(CH₂)_rNR²⁰(CH₂)_oR⁷⁷；R⁷⁴是-(CH₂)_pNR⁷⁸R⁷⁹；-(CH₂)_pNR⁷⁷R⁸⁰；-(CH₂)_pC(＝NR⁸⁰)NR⁷⁸R⁷⁹；-(CH₂)_pC(＝NOR⁵⁰)NR⁷⁸R⁷⁹；-(CH₂)_pC(＝NNR⁷⁸R⁷⁹)NR⁷⁸R⁷⁹；-(CH₂)_pNR⁸⁰C(＝NR⁸⁰)NR⁷⁸R⁷⁹；-(CH₂)_pN＝C(NR⁷⁸R⁸⁰)NR⁷⁹R⁸⁰；-(CH₂)_pC₆H₄NR⁷⁸R⁷⁹；-(CH₂)_pC₆H₄NR⁷⁷R⁸⁰；-(CH₂)_pC₆H₄C(＝NR⁸⁰)NR⁷⁹R⁷⁹；-(CH₂)_pC₆H₄C(＝NOR⁵⁰)NR⁷⁸R⁷⁹；-(CH₂)_pC₆H₄C(＝NNR⁷⁸R⁷⁹)NR⁷⁸R⁷⁹；-(CH₂)_pC₆H₄NR⁸⁰C(＝NR⁸⁰)NR⁷⁸R⁷⁹；-(CH₂)_pC₆H₄N＝C(NR⁷⁸R⁸⁰)NR⁷⁹R⁸⁰；-(CH₂)_rO(CH₂)_mNR⁷⁸R⁷⁹；-(CH₂)_rO(CH₂)_mNR⁷⁷R⁸⁰；-(CH₂)_rO(CH₂)_pC(＝NR⁸⁰)NR⁷⁸R⁷⁹；-(CH₂)_rO(CH₂)_pC(＝NOR⁵⁰)NR⁷⁸R⁷⁹；-(CH₂)_rO(CH₂)_pC(＝NNR⁷⁸R⁷⁹)NR⁷⁸R⁷⁹；-(CH₂)_rO(CH₂)_mNR⁸⁰C(＝NR⁸⁰)NR⁷⁸R⁷⁹；-(CH₂)_rO(CH₂)_mN＝C(NR⁷⁸R⁸⁰)NR⁷⁹R⁸⁰；-(CH₂)_rO(CH₂)_pC₆H₄CNR⁷⁸R⁷⁹；-(CH₂)_rO(CH₂)_pC₆H₄C(＝NR⁸⁰)NR⁷⁸R⁷⁹；-(CH₂)_rO(CH₂)_pC₆H₄C(＝NOR⁵⁰)NR⁷⁸R⁷⁹；-(CH₂)_rO(CH₂)_pC₆H₄C(＝NNR⁷⁸R⁷⁹)NR⁷⁸R⁷⁹；-(CH₂)_rO(CH₂)_pC₆H₄NR⁸⁰C(＝NR⁸⁰)NR⁷⁸R⁷⁹；-(CH₂)_rS(CH₂)_mNR⁷⁸R⁷⁹；-(CH₂)_rS(CH₂)_mNR⁷⁷R⁸⁰；-(CH₂)_rS(CH₂)_pC(＝NR⁸⁰)NR⁷⁸R⁷⁹；-(CH₂)_rS(CH₂)_pC(＝NOR⁵⁰)NR⁷⁸R⁷⁹；-(CH₂)_rS(CH₂)_pC(＝NNR⁷⁸R⁷⁹)NR⁷⁸R⁷⁹；-(CH₂)_rS(CH₂)_mNR⁸⁰C(＝NR⁸⁰)NR⁷⁸R⁷⁹；-(CH₂)_rS(CH₂)_mN＝C(NR⁷⁸R⁸⁰)NR⁷⁹R⁸⁰；-(CH₂)_rS(CH₂)_pC₆H₄CNR⁷⁸R⁷⁹；-(CH₂)_rS(CH₂)_pC₆H₄C(＝NR⁸⁰)NR⁷⁸R⁷⁹；-(CH₂)_rS(CH₂)_pC₆H₄C(＝NOR⁵⁰)NR⁷⁸R⁷⁹；-(CH₂)_rS(CH₂)_pC₆H₄C(＝NNR⁷⁸R⁷⁹)NR⁷⁸R⁷⁹；-(CH₂)_rS(CH₂)_pC₆H₄NR⁸⁰C(＝NR⁸⁰)NR⁷⁸R⁷⁹；-(CH₂)_pNR⁸⁰COR⁶⁴；-(CH₂)_pNR⁸⁰COR⁷⁷；-(CH₂)_pNR⁸⁰CONR⁷⁸R⁷⁹或-(CH₂)_pC₆H₄NR⁸⁰CONR⁷⁸R⁷⁹；R⁷⁵是低级烷基；低级链烯基或芳基-低级烷基；R³³和R⁷⁵一起可以形成：-(CH₂)_2-6-；-(CH₂)₂O(CH₂)₂-；-(CH₂)₂S(CH₂)₂-或-(CH₂)₂NR⁵⁷(CH₂)₂-；R⁷⁶和R⁸²一起可以形成：-(CH₂)_2-6-；-(CH₂)₂O(CH₂)₂-；-(CH₂)₂S(CH₂)₂-或-(CH₂)₂NR⁵⁷(CH₂)₂-；R⁷⁶是H；低级烷基；低级链烯基；芳基-低级烷基；-(CH₂)_oOR⁷²；-(CH₂)_oSR⁷²；-(CH₂)_oNR³³R³⁴；-(CH₂)_oOCONR³³R⁷⁵；-(CH₂)_oNR²⁰CONR³³R⁸²；-(CH₂)_oCOOR⁷⁵；-(CH₂)_oCONR⁵⁸R⁵⁹；-(CH₂)_oPO(OR⁶⁰)₂；-(CH₂)_pSO₂R⁶²或-(CH₂)_oCOR⁶⁴；R⁷⁷是-C₆R⁶⁷R⁶⁸R⁶⁹R⁷⁰R⁷⁶或下式之一的杂芳基R⁷⁸是H；低级烷基；芳基或芳基-低级烷基；R⁷⁸和R⁸²一起可以形成：-(CH₂)_2-6-；-(CH₂)₂O(CH₂)₂-；-(CH₂)₂S(CH₂)₂-或-(CH₂)₂NR⁵⁷(CH₂)₂-；R⁷⁹是H；低级烷基；芳基或芳基-低级烷基或R⁷⁸和R⁷⁹，连在一起，可以是-(CH₂)_2-7-；-(CH₂)₂O(CH₂)₂-或-(CH₂)₂NR⁵⁷(CH₂)₂-；R⁸⁰是H或低级烷基；R⁸¹是H；低级烷基或芳基-低级烷基；R⁸²是H；低级烷基；芳基；杂芳基或芳基-低级烷基；R³³和R⁸²一起可以形成：-(CH₂)_2-6-；-(CH₂)₂O(CH₂)₂-；-(CH₂)₂S(CH₂)₂-或-(CH₂)₂NR⁵⁷(CH₂)₂-；R⁸³是H；低级烷基；芳基或-NR⁷⁸R⁷⁹；R⁸⁴是-(CH₂)_m(CHR⁶¹)_sOH；-(CH₂)_pCONR⁷⁸R⁷⁹；-(CH₂)_pNR⁸⁰CONR⁷⁸R⁷⁹；-(CH₂)_pC₆H₄CONR⁷⁸R⁷⁹或-(CH₂)_pC₆H₄NR⁸⁰CONR⁷⁸R⁷⁹；R⁸⁵是低级烷基或低级链烯基；前提是在n个α-氨基酸残基的所述链Z、Z¹和Z²中-如果n是8，那么1-8位的氨基酸残基是：-P1：C类或D类或E类或F类，或者该残基是Pro； -P2：E类或D类或F类；-P3：E类或C类，或者该残基是Pro；-P4：E类或式-A-CO-；-P5：E类或式-B-CO-，或者该残基是Gly；-P6：D类，或者该残基是Pro；-P7：或类或C类或D类；和-P8：C类或D类或E类或F类，或者该残基是Pro；或P2和P7，连在一起，可以形成H类基团；并且在P4和P5也可以是D-异构体；-如果n是9，那么在1-9位的氨基酸残基是：-P1：C类或D类或E类或F类，或者该残基是Pro；-P2：E类或D类或F类；-P3：C类或D类或E类，或者该残基是Pro；-P4：E类或D类，或者该残基是Pro；-P5：E类，或者该残基是Gly或Pro；-P6：D类或E类，或者该残基是Gly或Pro；-P7：E类或D类或C类，或者该残基是Pro；-P8：E类或D类；和-P9：C类或D类或E类或F类，或者该残基是Pro或-P2和P8，连在一起，可以形成H类基团；并且在P4、P5和P6也可以是D-异构体；-如果n是10，那么在1-10位的氨基酸残基是：-P1：C类或D类或E类或F类，或者该残基是Pro；-P2：E类或D类，或者该残基是Pro；-P3：C类或E类；-P4：E类或D类或F类，或者该残基是Pro；-P5：E类或F类或式-A-CO-，或者该残基是Gly；-P6：E类或式-B-CO-，或者该残基是Gly；-P7：D类或E类，或者该残基是Gly或Pro；-P8：D类或E类；-P9：E类或D类或C类，或者该残基是Pro；和-P10：C类或D类或E类或F类或-P3和P8，连在一起，可以形成H类基团；并且在P5和P6也可以是D-异构体；-如果n是11，那么在1-11位的氨基酸残基是：-P1：C类或D类或E类或F类，或者该残基是Pro；-P2：E类或C类或D类；-P3：D类或E类，或者该残基是Pro；-P4：E类或C类或F类；-P5：E类或F类，或者该残基是Gly或Pro；-P6：E类或F类，或者该残基是Gly或Pro；-P7：E类或F类，或者该残基是Gly或Pro；-P8：D类或E类或F类；-P9：D类或E类，或者该残基是Pro；-P10：E类或C类或D类；和-P11：C类或D类或E类或F类，或者该残基是Pro或-P4和P8和/或P2和P10，连在一起，可以形成H类基团；并且在P5、P6和P7也可以是D-异构体；-如果n是12，那么在1-12位的氨基酸残基是：-P1：C类或D类或E类或F类，或者该残基是Pro；-P2：E类或D类；-P3：C类或D类，或者该残基是Pro；-P4：E类或F类或D类；-P5：E类或D类或C类，或者该残基是Gly或Pro；-P6：E类或F类或式-A-CO-，或者该残基是Gly；-P7：E类或F类或式-B-CO-；-P8：D类或C类，或者该残基是Pro；-P9：E类或D类或F类；-P10：D类或C类，或者该残基是Pro；-P11：E类或D类；和-P12：C类或D类或E类或F类，或者该残基是Pro或-P4和P9和/或P2和P11，连在一起，可以形成H类基团；并且在P6和P7也可以是D-异构体；-如果n是13，那么在1-13位的氨基酸残基是：-P1：C类或D类或E类或F类，或者该残基是Pro；-P2：E类或F类或D类；-P3：C类或D类或E类，或者该残基是Pro；-P4：E类或C类或F类；-P5：E类或D类，或者该残基是Gly或Pro；-P6：E类或F类，或者该残基是Gly或Pro；-P7：E类或F类，或者该残基是Pro；-P8：D类或E类或F类，或者该残基是Pro；-P9：D类或E类，或者该残基是Pro；-P10：E类或C类或F类；-P11：C类或E类，或者该残基是Pro；-P12：E类或D类或C类；和-P13：C类或D类或E类或F类，或者该残基是Pro或P4和P10和/或P2和P12，连在一起，可以形成H类基团；并且在P6、P7和P8也可以是D-异构体；-如果n是14，那么在1-14位的氨基酸残基是：-P1：C类或D类或E类或F类，或者该残基是Pro；-P2：E类或C类或D类，或者该残基是Pro；-P3：C类或D类或E类；-P4：D类或C类或E类，或者该残基是Pro；-P5：E类或D类；-P6：E类或F类，或者该残基是Gly或Pro；-P7：E类或F类或式-A-CO-，或者该残基是Gly；-P8：E类或F类或式-B-CO-，或者该残基是Gly；-P9：D类或E类，或者该残基是Pro；-P10：C类或D类或E类；-P11：E类或D类或F类，或者该残基是Pro；-P12：D类或E类；-P13：E类或C类或D类，或者该残基是Pro；和-P14：C类或D类或E类或F类，或者该残基是Pro或-P5和P10和/或P3和P12，连在一起，可以形成H类基团；并且在P7和P8也可以是D-异构体；-如果n是15，那么在1-15位的氨基酸残基是：P1：C类或D类或E类或F类，或者该残基是Pro；P2：E类或F类或D类；P3：C类或D类或E类，或者该残基是Pro；P4：E类或D类或F类；P5：C类或D类或E类，或者该残基是Pro；P6：E类或D类或F类；P7：C类或E类，或者该残基是Pro；P8：E类或F类，或者该残基是Gly或Pro；P9：E类或F类，或者该残基是Gly或Pro；P10：E类或D类；P11：C类或D类或E类，或者该残基是Pro；P12：E类或C类或F类；P13：D类或E类，或者该残基是Pro；P14：E类或C类或D类；和P15：C类或D类或E类或F类，或者该残基是Pro或P6和P10和/或P4和P12和/或P2和P14，连在一起，可以形成H类的基团；并且在P7、P8和P9也可以是D-异构体；和-如果n是16，那么在1-16位的氨基酸残基是：-P1：D类、或E类或C类或F类，或者该残基是Pro；-P2：E类或F类或D类；-P3：C类或D类或E类，或者该残基是Pro；-P4：E类或D类或F类；-P5：D类或C类或E类，或者该残基是Pro；-P6：E类或D类；-P7：E类或F类，或者该残基是Gly或Pro；-P8：E类或F类或式-A-CO-，或者该残基是Gly；-P9：E类或式-B-CO-，或者该残基是Gly；-P10：D类或E类，或者该残基是Pro；-P11：E类或C类或D类；-P12：D类或C类或E类，或者该残基是Pro；-P13：E类或C类或F类；-P14：C类或D类或E类，或者该残基是Pro；-P15：E类或C类或D类；和-P16：C类或D类或E类或F类，或者该残基是Pro或-P6和P11和/或P4和P13和/或P2和P15，连在-起，可以形成H类基团；并且在P8和P9也可以是D-异构体。