发明名称 |
Process for producing (dioxolenon-4-yl)methyl ester derivative |
摘要 |
There is provided a method by which various compounds (1) having a carboxyl group in the molecule have the carboxyl group converted to a (dioxolenon-4-yl)methyl ester at low cost, in a simple way and at high yield. The process for producing compounds of formula (3) according to the reaction scheme shown below comprises reacting carboxylic acids of formula (1) with 4-chloromethyldioxolenone compounds of formula (2) in a solvent in the presence of both a phase transfer catalyst and a metal iodide: [where Q represents an organic group, M represents a hydrogen atom, an alkali metal, an alkaline earth metal or a transition metal, R<SUB>1 </SUB>and R<SUB>2 </SUB>represent a hydrogen atom, an optionally substituted (C<SUB>1-6 </SUB>alkyl group or phenyl group)]. |
申请公布号 |
US7041820(B2) |
申请公布日期 |
2006.05.09 |
申请号 |
US20040473297 |
申请日期 |
2004.02.18 |
申请人 |
DAIICHI ASUBIO PHARMA CO., LTD. |
发明人 |
WATAI TOSHIYUKI;TAKASE MITSURU;SAGAE TAKAHIRO;MORI SHIGEO;KAWAHARA NORIAKI |
分类号 |
C07D499/08;C07D317/40;C07D499/00;C07D499/88;C07D499/897 |
主分类号 |
C07D499/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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