1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS

摘要

The present invention relates to a compound of the formula (I'): <IMG> or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 are independently C1-4 alkyl; R4 is phenyl substituted at 2-position with a C1-4 alkyl substituted with one or two substituents independently selected from the group consisting of amino, amino-C2-4 alkoxy, phenylthio, C1-4 alkyl- phenylthio, di-C1-4 alkylamino-C2-4 alkoxy, C1-4 alkylamino-C2-4 alkoxy, C1-4 alkylamino, di-C1-4 alkylamino, hydroxy, piperazinyl, oxopyrrolidinyl, pyrrolidinyl, morpholino, C1-4 alkylaminocarbonyl-C1-6 acylamino, C1-4 alkoxycarbonyl-C1-6 acylamino, C1-4 alkoxycarbonylpiperazinyl, C3-7 heterocyclic- C1-4 alkoxy and C1-6 acylpiperazinyl; and R5 is hydrogen or C1-4 alkyl.