发明名称 |
Anti-bacterial compounds directed against pilus biogenesis, adhesion and activity; co-crystals of pilus subunits and methods of use thereof |
摘要 |
Many Gram-negative pathogens assemble adhesive pili structures on their surfaces that allow them to colonize host tissues and cause disease. The present invention relates to novel compounds that mimic a chaperone G1 beta-strand or an amino terminal motif of a pilus subunit. The present invention also relates to the complex formed from the binding of such mimic compounds to the hydrophobic groove of a pilus subunit. Competitively interacting with the binding site of pili subunits will negatively affect the chaperone/usher pathway, which is one molecular mechanism by which Gram-negative bacteria assemble adhesive pili structures, and thus prevent or inhibit pilus assembly.
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申请公布号 |
US7041465(B1) |
申请公布日期 |
2006.05.09 |
申请号 |
US20000637216 |
申请日期 |
2000.08.11 |
申请人 |
WASHINGTON UNIVERSITY |
发明人 |
HULTGREN SCOTT J.;SAUER FREDERIC G.;WAKSMAN GABRIEL;FUETTERER KLAUS;CHOUDHURY DEVAPRIYA;KNIGHT STEFAN D.;BARNHART MICHELLE |
分类号 |
C12Q1/68;A61K38/00;C07K1/00;C12N1/20;G01N33/554 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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