发明名称 |
CANCER TREATMENT METHOD BY INHIBITING MAGE GENE EXPRESSION OR FUNCTION |
摘要 |
Method for inhibiting tumor cell formation or tumor cell growth, and method for inducing apoptosis in sperms, the method comprising administering to a patient in need thereof an antagonist that inhibits MAGE gene expression or MAGE protein function. Preferably, the antagonist is an anti-MAGE antibody, an antisense molecule, an siRNA molecule, a molecule for forming a triplex nucleic acid molecule with a MAGE encoding polynucleotide, or a small molecule inhibitor of MAGE function. Also disclosed are pharmaceutical compositions comprising the same, and method for screening a substance that inhibits MAGE gene expression of MAGE protein function. |
申请公布号 |
WO2005117974(A3) |
申请公布日期 |
2006.05.04 |
申请号 |
WO2005US18413 |
申请日期 |
2005.05.26 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION;LONGLEY, B., JACK;YANG, BING |
发明人 |
LONGLEY, B., JACK;YANG, BING |
分类号 |
A61K39/395;A61K48/00;C07K16/30;C12N15/113 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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