发明名称 |
A METHOD OF NUCLEIC ACID TYPING FOR SELECTING REGISTERED DONORS FOR CROSS-MATCHING TO TRANSFUSION RECIPIENTS |
摘要 |
<p>Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes-and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.</p> |
申请公布号 |
CA2584923(A1) |
申请公布日期 |
2006.05.04 |
申请号 |
CA20052584923 |
申请日期 |
2005.10.24 |
申请人 |
BIORRAY SOLUTIONS LTD.;NEW YORK BLOOD CENTER, INC. |
发明人 |
PIERCE, MICHAEL;REID, MARION E.;SEUL, MICHAEL;HASHMI, GHAZALA |
分类号 |
C12Q1/68;C12N15/12 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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