摘要 |
It is intended to provide an uracil derivative represented by the following general formula (I): (I) wherein X represents a group selected from among NHCO, NHCH<SUB>2</SUB>, CO, CONH and CH<SUB>2</SUB>NH; R<SUP>1 </SUP>represents hydrogen or optionally substituted C<SUB>1-6 </SUB>alkyl; R<SUP>2 </SUP>represents a group of the following general formula (II) or (III): (II) (III) (wherein m is 0 or 1; n is an integer of from 1 to 3; Y represents OH or NH<SUB>2</SUB>; and a dotted line shows a binding position), provided that when R<SUP>2 </SUP>is a group of the general formula (III), X represents NHCO or NHCH<SUB>2</SUB>; R<SUP>3 </SUP>and R<SUP>4 </SUP>independently represent each hydrogen or C<SUB>1-6 </SUB>alkyl; and Ar represents phenyl substituted by C<SUB>1-6 </SUB>alkyl at the o- and m-positions, optionally substituted heteroaryl or a bicyclic aromatic group; its pharmaceutically acceptable salt, and a remedy containing the above uracil derivative or its pharmaceutically acceptable salt as the active ingredient for, in particular, allergic diseases relating to a type IV allergic reaction, i.e., a novel compound useful in treating diseases in which a type IV allergic reaction participates and a remedy for allergic diseases containing the same as the active ingredient.
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