PROTEIN COMPRISING GnRH OR MUTATED GnRH LABELED WITH TECHNETIUM-99M

摘要

This invention produces scintigraphic imaging protein kind agents in human body for detecting the type of receptors on tumor cells and the site of tumor cells in vivo by labeling proteinS that are capable of specific-recognising tumor cells expressing gonadotropin releasing hormone (GnRH) receptor with technetium-99m. This kind of protein mainly comprises natural GnRH, mutated GnRH and targeting fusion proteins composed of them and derivatives of PE toxin, which are chiefly developed for using as targeting toxin substances to specifically kill some tumor cells that express GnRH receptor at present.