发明名称 |
TASTE-MASKED PHARMACEUTICAL COMPOSITIONS WITH GASTROSOLUBLE PORE-FORMERS |
摘要 |
There is provided a method for preparing an orally disintegrating tablet (ODT) composition comprising microparticles of one or more taste-masked active pharmaceutical ingredient(s), rapidly-dispersing microgranules, and other optional, pharmaceutically acceptable excipients wherein the ODT disintegrates on contact with saliva in the buccal cavity forming a smooth, easy-to-swallow suspension. Furthermore, the microparticles (crystals, granules, beads or pellets containing the active), coated with a taste-masking membrane comprising a water-insoluble polymer and one or more gastrosoluble inorganic or organic pore-formers (practically insoluble in water and saliva, but soluble in an acidic buffer), exhibit acceptable taste-masking when placed in the oral cavity and provide rapid, substantially-complete release of the dose on entry into the stomach. |
申请公布号 |
WO2006047493(A2) |
申请公布日期 |
2006.05.04 |
申请号 |
WO2005US38328 |
申请日期 |
2005.10.21 |
申请人 |
EURAND PHARMACEUTICALS LIMITED;LAI, JIN-WANG;VENKATESH, GOPI, M.;QIAN, KEN, KANGYI |
发明人 |
LAI, JIN-WANG;VENKATESH, GOPI, M.;QIAN, KEN, KANGYI |
分类号 |
A61K9/16;A61K9/50 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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