摘要 |
<p>A one-pot industrial process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazole-1-yl)methyl]-4H-carbazol-4-one of Formula-(I) from 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one of Formula-(IV) involves reaction of Formula (IV) with HNR<SUB>1</SUB>R<SUB>2</SUB> salt and paraformaldehyde, where R<SUB>1</SUB>,R<SUB>2</SUB> are independently alkyl groups or together forms a cyclic alkyl group, in a solvent system of acetic acid and hydrocarbon solvent to form a crude mixture of intermediate compounds of Formula (III) and (VIII), which is converted to ondansetron (Formula (I)) without isolation by reaction with 2methyimidazole in a suitable solvent system in the same pot.</p> |
申请人 |
IPCA LABORATORIES LIMITED;KUMAR, ASHOK;SINGH, DHARMENDRA;JADHAV, ATUL;PANDYA, DARPAN, NAVINCHANDRA;PANMAND, DEEPAK, SHANKAR;THAKUR, GAJENDRASINGH, RAMSINGH |
发明人 |
KUMAR, ASHOK;SINGH, DHARMENDRA;JADHAV, ATUL;PANDYA, DARPAN, NAVINCHANDRA;PANMAND, DEEPAK, SHANKAR;THAKUR, GAJENDRASINGH, RAMSINGH |